Meta-Analysis of Human Molecular Responses to Staphylococcus Aureus Components

Objective: This study is aimed to identify genes and pathways that are upregulated or downregulated by Staphylococcus aureus components using meta-analysis.Study Design: Meta-analysis of microarray Data.Place Duration Study: The was conducted at R.O. Perelman Department Dermatology, NYU Langone Medical Center, New York, USA, from January 2015 March 2015.Materials Methods: Public repository “GEO Datasets” searched key term “Staphylococcus aureus” for data sets covering effects S. infection in Homo sapiens cells. performed immune cell responses analyzed RankProd, RMAExpress, DAVID software. Results: secreted factors biofilm planktonic cultures predominantly induce adaptive process suppress mitotic cycle. biofilms conditioned media treated keratinocytes upregulate anti-apoptosis immunity while cycle as major cytoprotective process. Similar the cultures, superantigens innate challenged Panton Valentine Leukocidin (PVL) iPVL system a defensive mechanism. Importantly, these increased microbicidal activity host Conclusion: PVL could be potential priming agent myeloid cells against virulent infections. Further investigations into bactericidal ability will provide efficient therapy community-associated Meticillin-resistant (CA-MRSA)